Elena Topalidou was born in Athens. She studied dance at the State School of Orchestral Art and piano at the National Conservatory of Athens. As a dancer she was a key member of the OKTANA dance theater from 1993 to 2005 and participated in all its productions. She also collaborated with Dimitris Papaioannou and the Ground Team, the National Theatre, the State Theater of Northern Greece, the Rootless root group, etc. As an actor, she collaborated with the National Theatre, KTHBE, the Athens Festival, the House of Letters and Arts, etc. directed by Michael Marmarinou, Nikos Karathanos, Lefteris Vogiatzis, Lydias Koniordou, Kostantin Bogomolov, Akylla Karazisi, etc. In the cinema, she participated in Greek short and feature films. In 1999, she was awarded the prize for the best female performance for the performance The Lady with the Camellias, choreographed by Kostantinos Rigos. In 2020, she won the first female performance award for the short film Bella by Thelgia Petrakis. In 2022, she received the first female performance award at the Iris Awards of the Cinema Academy for the film Magnetic Fields by George Gousis. She has been teaching classical ballet at the National Opera School since 2011.